Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4(+)CD25(+) regulatory T cells

Studies on CD4(+)CD25(+) regulatory T cells (Tregs) with transgenic T-cell receptors indicate that Tregs may receive continuous antigen (Ag) stimulation in the periphery. However, the consequence of this Ag encounter and its relevance to physiologic polyclonal Treg function are not established. In a...

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Hauptverfasser: Setiady, Yulius Y., Ohno, Katsuhiro, Samy, Eileen T., Bagavant, Harini, Qiao, Hui, Sharp, Colin, She, Jin Xiong, Tung, Kenneth S. K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: © 2006 by The American Society of Hematology 2006
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895904/
https://ncbi.nlm.nih.gov/pubmed/16223778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3088
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