Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK–modified donor T cells after allogeneic hematopoietic cell transplantation

The introduction of an inducible suicide gene such as the herpes simplex virus thymidine kinase (HSV-TK) might allow exploitation of the antitumor activity of donor T cells after allogeneic hematopoietic cell transplantation (HCT) without graft versus host disease. However, HSV-TK is foreign, and im...

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Bibliographic Details
Main Authors: Berger, Carolina, Flowers, Mary E., Warren, Edus H., Riddell, Stanley R.
Format: Artigo
Language:Inglês
Published: The American Society of Hematology 2006
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895724/
https://ncbi.nlm.nih.gov/pubmed/16282341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3503
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