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A hepatitis A virus deletion mutant which lacks the first pyrimidine-rich tract of the 5' nontranslated RNA remains virulent in primates after direct intrahepatic nucleic acid transfection.

Cell culture-adapted variants of hepatitis A virus (HAV) in which the first pyrimidine-rich tract (pY1; nucleotides 99 to 138) of the 5' nontranslated region has been deleted (delta 96-137 or delta 96-139) replicate as well as parental virus in cultured cells (D.R. Shaffer, E.A. Brown, and S.M. Lemo...

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Udgivet i:J Virol
Principais autores: Shaffer, D R, Emerson, S U, Murphy, P C, Govindarajan, S, Lemon, S M
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189567/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7666566/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.10.6600-6604.1995
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