The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)–like disease

Dysregulated tyrosine kinase activity by the Fip1-like1 (FIP1L1)–platelet-derived growth factor receptor alpha (PDGFRA) (F/P) fusion gene has been identified as a cause of clonal hypereosinophilic syndrome (HES), called F/P-positive chronic eosinophilic leukemia (CEL) in humans. However, transplanta...

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Detalhes bibliográficos
Main Authors: Yamada, Yoshiyuki, Rothenberg, Marc E., Lee, Andrew W., Akei, Hiroko Saito, Brandt, Eric B., Williams, David A., Cancelas, Jose A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895281/
https://ncbi.nlm.nih.gov/pubmed/16418325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3153
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