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Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
Natural killer (NK) cells hold promise for improving the therapeutic potential of allogeneic hematopoietic transplantation, but their effectiveness is limited by inhibitory HLA types. We sought to overcome this intrinsic resistance by transducing CD56(+)CD3(-) NK cells with chimeric receptors direct...
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| Format: | Artigo |
| Sprache: | Inglês |
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© 2005 by The American Society of Hematology
2005
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895123/ https://ncbi.nlm.nih.gov/pubmed/15755898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-12-4797 |
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