PIG-A mutations in normal hematopoiesis

Paroxysmal nocturnal hemoglobinuria (PNH) is caused by phosphatidylinositol glycan–class A (PIG-A) mutations in hematopoietic stem cells (HSCs). PIG-A mutations have been found in granulocytes from most healthy individuals, suggesting that these spontaneous PIG-A mutations are important in the patho...

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Autors principals: Hu, Rong, Mukhina, Galina L., Piantadosi, Steven, Barber, Jamie P., Jones, Richard J., Brodsky, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: © 2005 by The American Society of Hematology 2005
Matèries:
Hematopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895084/
https://ncbi.nlm.nih.gov/pubmed/15687243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-04-1472
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