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Selection of an improved RNA polymerase ribozyme with superior extension and fidelity

Our current understanding of biology suggests that early life relied predominantly on RNA for catalysis and replication. Here, we report the isolation of an RNA polymerase ribozyme called B6.61 that exhibits superior extension and fidelity relative to its progenitor, the Round-18 polymerase. The B6....

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Main Authors: Zaher, Hani S., Unrau, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894930/
https://ncbi.nlm.nih.gov/pubmed/17586759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.548807
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