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Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1
Germline mutations in BRCA2 predispose to hereditary breast cancers. BRCA2 protein regulates recombinational repair by interaction with RAD51 via a series of degenerate BRC repeat motifs encoded by exon 11 (BRCA2(996–2113)), and an unrelated C-terminal domain (BRCA2(3265–3330)). BRCA2 is also requir...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1894777/ https://ncbi.nlm.nih.gov/pubmed/17541404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601739 |
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