Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci.

The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogen...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Arthur, M, Molinas, C, Bugg, T D, Wright, G D, Walsh, C T, Courvalin, P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189469/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1503450/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.4.867
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