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Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores.

S-1108, the prodrug of S-1006, was given to healthy volunteers three times a day (TID) for 8 days in a dose of 200 mg in a crossover placebo-controlled study. The safety of S-1108 and the pharmacokinetics of S-1006 and pivalic acid liberated from pivaloyloxymethyl ester of S-1108 were investigated....

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Bibliografske podrobnosti
Main Authors: Nakashima, M, Uematsu, T, Oguma, T, Yoshida, T, Mizojiri, K, Matsuno, S, Yamamoto, S
Format: Artigo
Jezik:Inglês
Izdano: 1992
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC189394/
https://ncbi.nlm.nih.gov/pubmed/1503438
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