Lactate dehydrogenase-elevating virus replication persists in liver, spleen, lymph node, and testis tissues and results in accumulation of viral RNA in germinal centers, concomitant with polyclonal activation of B cells.

Lactate dehydrogenase-elevating virus (LDV) replicates primarily and most likely solely in a subpopulation of macrophages in extraneuronal tissues. Infection of mice, regardless of age, with LDV leads to the rapid cytocidal replication of the virus in these cells, resulting in the release of large a...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Anderson, G W, Rowland, R R, Palmer, G A, Even, C, Plagemann, P G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189342/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7609091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.8.5177-5185.1995
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