Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels.

Approximately 15% of BXH-2 myeloid leukemias harbor proviral integrations at the Evi-2 common viral integration site. Evi-2 is located within a large intron of the Nf1 tumor suppressor gene, raising the possibility that proviral integration at Evi-2 predisposes mice to myeloid tumor development by d...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Largaespada, D A, Shaughnessy, J D, Jenkins, N A, Copeland, N G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189327/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7609078/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.8.5095-5102.1995
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