O-Specific polysaccharide conjugate vaccine-induced IgG antibodies prevent invasion of Shigella into Caco-2 cells and may be curative

The O-specific polysaccharide (O-SP) domain of Shigella LPS is both an essential virulence factor and a protective antigen for this genus. A critical level of serum IgG anti-O-SP was shown to confer immunity to shigellosis, likely by complement-mediated bacteriolysis of the inoculum. Conjugate Shige...

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Detalhes bibliográficos
Main Authors: Chowers, Yehuda, Kirschner, Joachim, Keller, Nathan, Barshack, Iris, Bar-Meir, Simon, Ashkenazi, Shai, Schneerson, Rachel, Robbins, John, Passwell, Justen H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892925/
https://ncbi.nlm.nih.gov/pubmed/17287349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610833104
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