The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

Liver insufficiency and damage is a major cause of death and disease worldwide and may result from exposure to environmental toxicants, specific combinations or dosages of pharmaceuticals and microbial metabolites. The generation of reactive intermediates, in particular 4-hydroxynonenal (4-HNE), is...

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Detalhes bibliográficos
Main Authors: Coleman, Jeffrey D., Prabhu, K. Sandeep, Thompson, Jerry T., Reddy, P. Sreenivasula, Peters, Jeffrey M., Peterson, Blake R., Reddy, C. Channa, Vanden Heuvel, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892209/
https://ncbi.nlm.nih.gov/pubmed/17382197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.01.003
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