The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

Liver insufficiency and damage is a major cause of death and disease worldwide and may result from exposure to environmental toxicants, specific combinations or dosages of pharmaceuticals and microbial metabolites. The generation of reactive intermediates, in particular 4-hydroxynonenal (4-HNE), is...

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Main Authors: Coleman, Jeffrey D., Prabhu, K. Sandeep, Thompson, Jerry T., Reddy, P. Sreenivasula, Peters, Jeffrey M., Peterson, Blake R., Reddy, C. Channa, Vanden Heuvel, John P.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892209/
https://ncbi.nlm.nih.gov/pubmed/17382197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.01.003
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