Structural basis of the recognition of a methylated histone tail by JMJD2A

The Jumonji C domain is a catalytic motif that mediates histone lysine demethylation. The Jumonji C-containing oxygenase JMJD2A specifically demethylates tri- and dimethylated lysine-9 and lysine-36 of histone 3 (H3K9/36me3/2). Here we present structures of the JMJD2A catalytic core complexed with m...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chen, Zhongzhou, Zang, Jianye, Kappler, John, Hong, Xia, Crawford, Frances, Wang, Qin, Lan, Fei, Jiang, Chengyu, Whetstine, Johnathan, Dai, Shaodong, Hansen, Kirk, Shi, Yang, Zhang, Gongyi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2007
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891149/
https://ncbi.nlm.nih.gov/pubmed/17567753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704525104
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