Selective depletion of stored calcium by thapsigargin blocks rotavirus maturation but not the cytopathic effect.

Rotavirus matures inside the endoplasmic reticulum (ER), a site of intracellular calcium storage. Total cell Ca2+ depletion has been shown to impair virus maturation, arresting this process at the membrane-enveloped intermediate form following its budding into the ER. On the other hand, rotavirus in...

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Библиографические подробности
Главные авторы: Michelangeli, F, Liprandi, F, Chemello, M E, Ciarlet, M, Ruiz, M C
Формат: Artigo
Язык:Inglês
Опубликовано: 1995
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC189102/
https://ncbi.nlm.nih.gov/pubmed/7745732
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