Brucella abortus conjugated with a gp120 or V3 loop peptide derived from human immunodeficiency virus (HIV) type 1 induces neutralizing anti-HIV antibodies, and the V3-B. abortus conjugate is effective even after CD4+ T-cell depletion.

Human immunodeficiency virus type 1 (HIV-1) infection is associated with loss of function and numbers of CD4+ T-helper cells. In order to bypass the requirement for CD4+ cells in antibody responses, we have utilized heat-inactivated Brucella abortus as a carrier. In this study we coupled a 14-mer V3...

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Pubblicato in:	J Virol
Autori principali:	Golding, B, Inman, J, Highet, P, Blackburn, R, Manischewitz, J, Blyveis, N, Angus, R D, Golding, H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189041/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7745677/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.6.3299-3307.1995
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