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Anti-calmodulins and Tricyclic Adjuvants in Pain Therapy Block the TRPV1 Channel
Ca(2+)-loaded calmodulin normally inhibits multiple Ca(2+)-channels upon dangerous elevation of intracellular Ca(2+) and protects cells from Ca(2+)-cytotoxicity, so blocking of calmodulin should theoretically lead to uncontrolled elevation of intracellular Ca(2+). Paradoxically, classical anti-psych...
Tallennettuna:
| Päätekijät: | , , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science
2007
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1890308/ https://ncbi.nlm.nih.gov/pubmed/17579717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000545 |
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