Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus.

We have identified the major cellular endoprotease that activates the fusion (F) glycoprotein of measles virus (MV) and have engineered a serine protease inhibitor (serpin) to target the endoprotease and inhibit the production of infectious MV. The F-protein precursor of MV was not cleaved efficient...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Watanabe, M, Hirano, A, Stenglein, S, Nelson, J, Thomas, G, Wong, T C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189026/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7707552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.5.3206-3210.1995
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