Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres

Phosphorylated histone H2AX (γH2AX) is generated in nucleosomes flanking sites of DNA double-strand breaks, triggering the recruitment of DNA-damage response proteins such as MDC1 and 53BP1. Here, we study shortened telomeres in senescent human cells. We show that most telomeres trigger γH2AX format...

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Bibliografiske detaljer
Main Authors: Meier, Andreas, Fiegler, Heike, Muñoz, Purificacion, Ellis, Peter, Rigler, Diane, Langford, Cordelia, Blasco, Maria A, Carter, Nigel, Jackson, Stephen P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888678/
https://ncbi.nlm.nih.gov/pubmed/17491589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601719
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