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Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres
Phosphorylated histone H2AX (γH2AX) is generated in nucleosomes flanking sites of DNA double-strand breaks, triggering the recruitment of DNA-damage response proteins such as MDC1 and 53BP1. Here, we study shortened telomeres in senescent human cells. We show that most telomeres trigger γH2AX format...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1888678/ https://ncbi.nlm.nih.gov/pubmed/17491589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601719 |
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