Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation.

Hepatitis B virus is a major risk factor in human hepatocellular carcinomas. We have used protein affinity chromatography to show that the 17-kDa hepatitis B virus gene product, HBx, binds directly to the human tumor suppressor gene product, p53. Interaction of HBx with p53 did not prevent p53 from...

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Vydáno v:	J Virol
Hlavní autoři:	Truant, R, Antunovic, J, Greenblatt, J, Prives, C, Cromlish, J A
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1995
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188796/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7853526/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.3.1851-1859.1995
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