Thymic epithelial defects and predisposition to autoimmune disease in BB rats.

We report an association between thymic epithelial defects and predisposition to autoimmunity. Diabetes-prone (DP) BB rats develop spontaneous hyperglycemia and are deficient in T cell subsets expressing the RT6 alloantigen. Diabetes resistant (DR) BB rats become diabetic if depleted of RT6+ T cells...

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Main Authors: Doukas, J., Mordes, J. P., Swymer, C., Niedzwiecki, D., Mason, R., Rozing, J., Rossini, A. A., Greiner, D. L.
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887500/
https://ncbi.nlm.nih.gov/pubmed/7992854
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