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Chemical synthesis and spontaneous folding of a multidomain protein: Anticoagulant microprotein S
Because of recent high-yield native ligation techniques, chemical synthesis of larger multidomain bioactive proteins is rapidly coming within reach. Here we describe the total chemical synthesis of a designed “microprotein S,” comprising the γ-carboxyglutamic acid-rich module, the thrombin-sensitive...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC18873/ https://ncbi.nlm.nih.gov/pubmed/11106381 |
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