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Interleukin-4 down-regulates adult human astrocyte DNA synthesis and proliferation.

The T lymphocyte-derived cytokine, interleukin-4 (IL-4), was found to inhibit dose dependently basal DNA synthesis of cultured non-neoplastic human astrocytes isolated from epilepsy white matter tissue. The mitogenic effect of tumor necrosis factor on astrocytes was also inhibited by IL-4, and the i...

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Autori principali: Estes, M. L., Iwasaki, K., Jacobs, B. S., Barna, B. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1993
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887009/
https://ncbi.nlm.nih.gov/pubmed/8342591
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