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Abnormal isoform of prion proteins accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt-Jakob disease.

A new method, which enabled the first immunohistochemical documentation of abnormal prion protein (PrP) in all patients with Creutzfeldt-Jakob disease (CJD), was established. This method designated as "hydrolytic autoclaving" revealed punctate PrPCJD stainings around the neuronal cell bodi...

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Detalhes bibliográficos
Main Authors: Kitamoto, T., Shin, R. W., Doh-ura, K., Tomokane, N., Miyazono, M., Muramoto, T., Tateishi, J.
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1886543/
https://ncbi.nlm.nih.gov/pubmed/1351366
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