Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes.

We used reovirus reassortant genetics and severe combined immunodeficient (SCID) mice to define viral genes important for organ tropism and virulence in the absence of antigen-specific immunity. Adult SCID mice infected with reovirus serotype 1 strain Lang (T1L) died after 20 +/- 6 days, while infec...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Haller, B L, Barkon, M L, Vogler, G P, Virgin, H W
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188583/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7983730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.1.357-364.1995
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