Ligation of α4β1 Integrin on Human Intestinal Mucosal Mesenchymal Cells Selectively Up-Regulates Membrane Type-1 Matrix Metalloproteinase and Confers a Migratory Phenotype

Human intestinal lamina propria mesenchymal cells show high surface expression of the α4β1 integrin. Ligation of α4β1 on mesenchymal cell lines with an activating monoclonal anti-α4 antibody or vascular cell adhesion molecule-immunoglobulin (VCAM-IgG) leads to the appearance of activated forms of ge...

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Main Authors: Pender, Sylvia L. F., Salmela, Mikko T., Monteleone, Giovanni, Schnapp, Denni, McKenzie, Catriona, Spencer, Jo, Fong, Sherman, Saarialho-Kere, Ulpu, MacDonald, Thomas T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2000
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885781/
https://ncbi.nlm.nih.gov/pubmed/11106568
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