Inhibition of p53 Function Prevents Renin-Angiotensin System Activation and Stretch-Mediated Myocyte Apoptosis

To determine whether stretch-induced activation of p53 is necessary for the up-regulation of the local renin-angiotensin system and angiotensin II (Ang II)-induced apoptosis, ventricular myocytes were infected with an adenoviral vector carrying mutated p53, Adp53m, before 12 hours of stretch. Noninf...

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Hauptverfasser: Leri, Annarosa, Fiordaliso, Fabio, Setoguchi, Manabu, Limana, Federica, Bishopric, Nanette H., Kajstura, Jan, Webster, Keith, Anversa, Piero
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885708/
https://ncbi.nlm.nih.gov/pubmed/10980124
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