Insulin-Like Growth Factor-1 Induces Mdm2 and Down-Regulates p53, Attenuating the Myocyte Renin-Angiotensin System and Stretch-Mediated Apoptosis

Insulin-like growth factor (IGF)-1 inhibits apoptosis, but its mechanism is unknown. Myocyte stretching activates p53 and p53-dependent genes, leading to the formation of angiotensin II (Ang II) and apoptosis. Therefore, this in vitro system was used to determine whether IGF-1 interfered with p53 fu...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Leri, Annarosa, Liu, Yu, Claudio, Pier Paolo, Kajstura, Jan, Wang, Xiaowei, Wang, Shenglun, Kang, Parminder, Malhotra, Ashwani, Anversa, Piero
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Investigative Pathology 1999
Pynciau:
Regular Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850006/
https://ncbi.nlm.nih.gov/pubmed/10027414
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