Defective RNA replication by poliovirus mutants deficient in 2A protease cleavage activity.

2A protease (2Apro) catalyzes the initial cleavage of the poliovirus polyprotein which separates the P1 structural protein precursor from the P2-P3 nonstructural protein precursor. In addition, 2Apro indirectly induces cleavage of the p220 component of eukaryotic initiation factor 4F, which is thoug...

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Bibliographic Details
Main Authors: Yu, S F, Benton, P, Bovee, M, Sessions, J, Lloyd, R E
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC188570/
https://ncbi.nlm.nih.gov/pubmed/7983716
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