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In vitro erythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds

The goal of this study was to create an in vitro cell culture system that captures essential features of the in vivo erythroid micronucleus (MN) genotoxicity assay, thus enabling increased throughput and controlled studies of the hematopoietic DNA damage response. We show that adult bone marrow (BM)...

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Detalhes bibliográficos
Main Authors: Shuga, J., Zhang, J., Samson, L. D., Lodish, H. F., Griffith, L. G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885572/
https://ncbi.nlm.nih.gov/pubmed/17502613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701829104
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