Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival

A gene expression signature of tumor proliferation rate in mantle cell lymphoma (MCL) is an overriding molecular predictor of the length of survival following diagnosis. Many strongly proliferative MCL tumors have exceptionally high cyclin D1 mRNA levels and preferentially express short cyclin D1 mR...

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Bibliografische gegevens
Hoofdauteurs: Wiestner, Adrian, Tehrani, Mahsa, Chiorazzi, Michael, Wright, George, Gibellini, Federica, Nakayama, Kazutaka, Liu, Hui, Rosenwald, Andreas, Muller-Hermelink, H. Konrad, Ott, German, Chan, Wing C., Greiner, Timothy C., Weisenburger, Dennis D., Vose, Julie, Armitage, James O., Gascoyne, Randy D., Connors, Joseph M., Campo, Elias, Montserrat, Emilio, Bosch, Francesc, Smeland, Erlend B., Kvaloy, Stein, Holte, Harald, Delabie, Jan, Fisher, Richard I., Grogan, Thomas M., Miller, Thomas P., Wilson, Wyndham H., Jaffe, Elaine S., Staudt, Louis M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2007
Onderwerpen:
Plenary Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885523/
https://ncbi.nlm.nih.gov/pubmed/17299095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-08-039859
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