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Structural and Functional Consequences of Coenzyme Binding to the Inactive Asian Variant of Mitochondrial Aldehyde Dehydrogenase: Roles of Residues 475 and 487
The common ALDH2*2 polymorphism is associated with impaired ethanol metabolism and decreased efficacy of nitroglycerin treatment. These physiological effects are due to the substitution of Lys for Glu 487 that reduces the k(cat) for these processes and increases the K(M) for NAD(+), as compared to A...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1885376/ https://ncbi.nlm.nih.gov/pubmed/17327228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M607959200 |
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