High-Threshold Mechanosensitive Ion Channels Blocked by a Novel Conopeptide Mediate Pressure-Evoked Pain

Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons. One conopeptide analogue, termed NMB-1 for noxious mechanosensation blocker 1, s...

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Detalhes bibliográficos
Main Authors: Drew, Liam J., Rugiero, Francois, Cesare, Paolo, Gale, Jonathan E., Abrahamsen, Bjarke, Bowden, Sarah, Heinzmann, Sebastian, Robinson, Michelle, Brust, Andreas, Colless, Barbara, Lewis, Richard J., Wood, John N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885214/
https://ncbi.nlm.nih.gov/pubmed/17565368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000515
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