A population-based assessment of the potential interaction between serotonin-specific reuptake inhibitors and digoxin

AIM: In vitro evidence suggests that some serotonin-specific reuptake inhibitors (SSRIs) inhibit P-glycoprotein, a multidrug efflux pump responsible for the elimination of several drugs including digoxin. We sought to determine if some SSRIs cause digoxin toxicity in the clinical setting. METHODS: P...

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Detalhes bibliográficos
Main Authors: Juurlink, David N, Mamdani, Muhammad M, Kopp, Alexander, Herrmann, Nathan, Laupacis, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884963/
https://ncbi.nlm.nih.gov/pubmed/15606447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02230.x
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