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Kidneys contribute to the extrahepatic clearance of propofol in humans, but not lungs and brain

AIMS: The principal site for the metabolism of propofol is the liver. However, the total body clearance of propofol is greater than the generally accepted hepatic blood flow. In this study, we determined the elimination of propofol in the liver, lungs, brain and kidneys by measuring the arterial-ven...

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Detalhes bibliográficos
Main Authors: Hiraoka, Haruhiko, Yamamoto, Koujirou, Miyoshi, Soutarou, Morita, Toshihiro, Nakamura, Katsunori, Kadoi, Yuuji, Kunimoto, Fumio, Horiuchi, Ryuya
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884930/
https://ncbi.nlm.nih.gov/pubmed/16042671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02393.x
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