Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease

Endothelial protein C receptor (EPCR) and thrombomodulin (TM) are expressed at high levels in the resting microvasculature and convert protein C (PC) into its activated form, which is a potent anticoagulant and antiinflammatory molecule. Here we provide evidence that in Crohn disease (CD) and ulcera...

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Hauptverfasser: Scaldaferri, Franco, Sans, Miquel, Vetrano, Stefania, Graziani, Cristina, De Cristofaro, Raimondo, Gerlitz, Bruce, Repici, Alessandro, Arena, Vincenzo, Malesci, Alberto, Panes, Julian, Grinnell, Brian W., Danese, Silvio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884689/
https://ncbi.nlm.nih.gov/pubmed/17557119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31027
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