Metabolism and pharmacokinetics of the anti-varicella-zoster virus agent 6-dimethylaminopurine arabinoside.

The metabolism of 6-dimethylaminopurine arabinoside (ara-DMAP), a potent inhibitor of varicella-zoster virus replication in vitro, was studied in rats and cynomolgus monkeys. Rats dosed intraperitoneally or orally with ara-DMAP excreted unchanged ara-DMAP and one major metabolite, 6-methylaminopurin...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Lambe, C U, Resetar, A, Spector, T, Koszalka, G W, Nelson, D J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1318679/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.2.353
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