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Effect of omeprazole on the steady-state pharmacokinetics of voriconazole
AIMS: Voriconazole, a novel triazole antifungal agent, is metabolized by the cytochrome P450 isoenzymes CYP2C19, CYP2C9, and to a lesser extent by CYP3A4. Omeprazole, a proton pump inhibitor used widely for the treatment of gastric and duodenal ulcers, is predominantly metabolized by CYP2C19 and CYP...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Blackwell Science Inc
2003
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1884317/ https://ncbi.nlm.nih.gov/pubmed/14616415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.02000.x |
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