Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome

AIMS: To verify that Gilbert's syndrome, which is caused by decreased glucuronidation capacity of the UDP-glucuronosyl transferase (UGT)1A1, does not account for impaired morphine clearance. METHODS: Noncompartmental pharmacokinetic parameters for morphine and its glucuronide metabolites were c...

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Autores principales: Skarke, Carsten, Schmidt, Helmut, Geisslinger, Gerd, Darimont, Jutta, Lötsch, Jörn
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2003
Materias:
Short Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884272/
https://ncbi.nlm.nih.gov/pubmed/12895198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01866.x
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