Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4(+) T cells

We examined how cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates heterogeneous CD4(+) T cell responses by using experimental autoimmune encephalomyelitis (EAE), a CD4(+) T cell-mediated disease that is subject to regulation by CTLA-4. Disease incidence and severity were used as measures of in viv...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Kuhns, Michael S., Epshteyn, Victoria, Sobel, Raymond A., Allison, James P.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18829/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11050166/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.220423597
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