Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4(+) T cells

We examined how cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates heterogeneous CD4(+) T cell responses by using experimental autoimmune encephalomyelitis (EAE), a CD4(+) T cell-mediated disease that is subject to regulation by CTLA-4. Disease incidence and severity were used as measures of in viv...

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Bibliografiske detaljer
Main Authors: Kuhns, Michael S., Epshteyn, Victoria, Sobel, Raymond A., Allison, James P.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18829/
https://ncbi.nlm.nih.gov/pubmed/11050166
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