Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats.

Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clini...

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Bibliographic Details
Main Authors: Yoshiyama, Y, Nishikawa, S, Sugiyama, T, Kobayashi, T, Shimada, H, Tomonaga, F, Ohdo, S, Ogawa, N, Nakano, S
Format: Artigo
Language:Inglês
Published: 1993
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC188120/
https://ncbi.nlm.nih.gov/pubmed/8239630
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