Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes.

At nonpermissive temperatures the peptidyl-tRNA hydrolase of pth(Ts) bacterial mutants is inactivated, and cells accumulate peptidyl-tRNA and die. Doses of erythromycin, lincomycin, or clindamycin that inhibited the growth of antibiotic-hypersensitive DB-11 pth+ cells accelerated the killing of DB-1...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Menninger, J R, Coleman, R A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188116/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8239627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.9.2027
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