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Timing of hepatocyte entry into DNA synthesis after partial hepatectomy is cell autonomous

After surgical removal of two-thirds of the liver, remaining hepatocytes replicate and restore hepatic mass within 2 weeks. This process must be initiated by signals extrinsic to the hepatocyte, but it remains unclear whether subsequent events leading to DNA synthesis (S phase) are regulated by circ...

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Bibliografiske detaljer
Main Authors: Weglarz, Teresa C., Sandgren, Eric P.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18809/
https://ncbi.nlm.nih.gov/pubmed/11050176
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