Synergistic combinations of Ro 11-8958 and other dihydrofolate reductase inhibitors with sulfamethoxazole and dapsone for therapy of experimental pneumocystosis.

We compared Ro 11-8958, an analog of trimethoprim (TMP) with improved antimicrobial and pharmacokinetic properties, other dihydrofolate reductase (DHFR) inhibitors, sulfamethoxazole (SMX), and dapsone (DAP) in the treatment of Pneumocystis carinii pneumonia in an immunosuppressed rat model. In contr...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Walzer, P D, Foy, J, Steele, P, White, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187990/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8363372/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.7.1436
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