Cell cycle perturbation and cell death after exposure of a human lymphoblastoid cell strain to N-methyl-N'-nitro-N-nitrosoguanidine.

The mechanisms involved in cell death caused by carcinogens that methylate DNA are poorly understood. In this study, the cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was studied in exponentially growing T5-1 human lymphoblastoid cells. MNNG exposure killed cells and inhibited pro...

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Main Authors: Black, K. A., McFarland, R. D., Grisham, J. W., Smith, G. J.
Formato: Artigo
Idioma:Inglês
Publicado: 1989
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1879564/
https://ncbi.nlm.nih.gov/pubmed/2913827
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