Selective inhibition of the bacterial translocase reaction in peptidoglycan synthesis by mureidomycins.

Mureidomycins (MRDs) A and C inhibited strongly the formation of undecaprenyl pyrophosphoryl N-acetylmuramyl-pentapeptide (lipid intermediate I), which is an intermediate in bacterial peptidoglycan synthesis (50% inhibitory concentration [IC50] of MRD A, 0.05 microgram/ml). However, they did not inh...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Inukai, M, Isono, F, Takatsuki, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187869/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8517724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.5.980
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