Kill kinetics and regrowth patterns of Escherichia coli exposed to gentamicin concentration-time profiles simulating in vivo bolus and infusion dosing.

The relative influence of peak concentration (Cmax) versus the area under the antibiotic concentration-time curve (AUC) on the bactericidal effect of gentamicin against Escherichia coli NCTC 10418 was studied. Bacteria in the lag phase were exposed to an in vitro gentamicin concentration series whic...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Bastone, E B, Li, S C, Ioannides-Demos, L L, Spicer, W J, McLean, A J
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187813/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8494392/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.4.914
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