Backbone Structure of the Amantadine-Blocked Trans-Membrane Domain M2 Proton Channel from Influenza A Virus

Amantadine is known to block the M2 proton channel of the Influenza A virus. Here, we present a structure of the M2 trans-membrane domain blocked with amantadine, built using orientational constraints obtained from solid-state NMR polarization-inversion-spin-exchange-at-the-magic-angle experiments....

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Bibliographic Details
Main Authors: Hu, Jun, Asbury, Tom, Achuthan, Srisairam, Li, Conggang, Bertram, Richard, Quine, Jack R., Fu, Riqiang, Cross, Timothy A.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2007
Subjects:
Channels, Receptors, and Electrical Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1877758/
https://ncbi.nlm.nih.gov/pubmed/17384070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.090183
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