Comparative pharmacokinetics of two prodrugs of zidovudine in rabbits: enhanced levels of zidovudine in brain tissue.

The pharmacokinetics of two prodrugs of zidovudine (AZT), 1,4-dihydro-1-methyl-3-[(pyridylcarbonyl)oxy] ester and isoleucinyl ester (DPAZT and IAZT, respectively), were investigated in a rabbit model to determine their potential utility as drugs against human immunodeficiency virus. Drugs were admin...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Lupia, R H, Ferencz, N, Lertora, J J, Aggarwal, S K, George, W J, Agrawal, K C
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1993
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187771/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8494380/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.4.818
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